Recombinant Human HPGDS/GSTS Protein

Specifications

Catalog number

PKSH032528-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH (2) . HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydroperoxide.

Abbreviation

HPGDS; GSTS

Synonyms

GST Class-Sigma; GSTS; Glutathione S-Transferase; Glutathione-Dependent PGD Synthase; Glutathione-Requiring Prostaglandin D Synthase; H-PGDS; HPGDS; Hematopoietic Prostaglandin D Synthase; PGDS; PTGDS2; Prostaglandin-H2 D-Isomerase

UniProt

O60760

Accession Number

O60760

Expression System

E.coli

Tag

None

Sequence

Met 1-Leu199

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

22.3 kDa

Observed Molecular Weight

26 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 7.0.

Species

Human