Recombinant Human Hepcidin/HAMP Protein (GST Tag)

Specifications

Catalog number

PKSH032540-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hepcidin (HAMP) is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures.

Abbreviation

Hepcidin; HAMP

Synonyms

HEPC; LEAP1; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor

UniProt

P81172

Accession Number

P81172

Expression System

E.coli

Tag

N-GST

Sequence

Asp60-Thr84

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

29.2 kDa

Observed Molecular Weight

28-30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.

Species

Human