Recombinant Human HMGB2 Protein (His Tag)

Specifications

Catalog number

PKSH032545-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination.

Abbreviation

HMGB2

Synonyms

HMG-2; HMG2; HMGB2; High Mobility Group Protein 2; High Mobility Group Protein B2

UniProt

P26583

Accession Number

P26583

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gly2-Glu209

Field of Research

Epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.1 kDa

Observed Molecular Weight

28 kDa

Species

Human