Recombinant Human Hyaluronidase-1/HYAL1 Protein (His Tag)

Specifications

Catalog number

PKSH032552-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Abbreviation

Hyaluronidase-1; HYAL1

Synonyms

HYAL1; Hyal-1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LUCA1; LuCa-1; Lung Carcinoma Protein 1

UniProt

Q12794

Accession Number

Q12794

Expression System

HEK293 Cells

Tag

C-His

Sequence

Phe22-Trp435

Field of Research

Signal Transduction; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

47.2 kDa

Observed Molecular Weight

50-65 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.

Species

Human