Recombinant Human IA2/PTPRN Protein (aa 607-Asn686 & aa 795-888, His Tag)

Specifications

Catalog number

PKSH032555-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain; is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules; such as their biogenesis; trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity; may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera; and thus may be a potential target of autoimmunity in diabetes mellitus.

Abbreviation

IA2; PTPRN

Synonyms

ICA 512; ICA3; ICA512; Islet cell antigen 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; R-PTP-N; Receptor-type tyrosine-protein phosphatase-like N

UniProt

Q16849

Accession Number

Q16849

Expression System

E.coli

Tag

N-His

Sequence

Gln607-Asn686&Trp795-Leu888

Field of Research

Signal Transduction; Neuroscience; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

22.9 kDa

Observed Molecular Weight

26-30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 8.0.

Species

Human