Recombinant Human IL-1RAcP/IL1R3 Protein (Fc & His Tag)

Specifications

Catalog number

PKSH032559-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α; IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1; TOLLIP; MYD88; and IRAK1 or IRAK2. In addition; IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Abbreviation

IL-1RAcP; IL1R3

Synonyms

IL1R; Interleukin-1 Receptor; C3orf; IL-1 Receptor Accessory Protein; IL-1R3; IL-1R-3; IL-1RAcP; Interleukin-1 Receptor 3; Interleukin-1 Receptor Accessory Protein; C3orf13; IL1R3; IL1RAP; FLJ37788; IL 1 receptor accessory protein; IL 1R3; IL 1RAcP; IL 1RAP; Interleukin 1 Accessory Protein; interleukin 1 receptor 3; Interleukin 1 receptor accessory protein

UniProt

Q9NPH3

Accession Number

Q9NPH3-2

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Ser21-Gln356

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

66.7 kDa

Observed Molecular Weight

80-100 kDa

Species

Human