Recombinant Human IL10RB/IL10R2 Protein (Fc Tag)

Specifications

Catalog number

PKSH032564-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-10 receptor subunit beta (IL10RB), also known as Cytokine receptor class-II member 4, Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.

Abbreviation

IL10RB; IL10R2

Synonyms

CRFB; Interleukin-10 receptor subunit; Cytokine receptor class-II member; Cytokine receptor family 2 member; CRF2; IL-10R; CDW210B; CRF2-4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; IL-10R2; Interleukin-10 receptor subunit 2; Interleukin-10 receptor subunit beta (IL10RB) ; IL10RB; CRFB4; D21S58; D21S66; CRF2-4; IL-10Rb; Cd210; CRF2 4; Cytokine receptor class II; Cytokine receptor class II CRF2 4; Cytokine receptor family II member 4; I10R2; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL10R2; IL-10RB; Interleukin 10 receptor beta; Interleukin-10 receptor subunit beta

UniProt

Q08334

Accession Number

Q08334

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Met20-Ser220

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

50.6 kDa

Observed Molecular Weight

75-95 kDa

Species

Human