Recombinant Human IL15RA/IL-15RA Protein (Fc Tag)

Specifications

Catalog number

PKSH032566-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.

Abbreviation

IL15RA; IL-15RA

Synonyms

MGC; IL15RA; CD215; alpha; CD215 antigen; IL-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; interleukin 15 receptor; interleukin-15 receptor subunit alpha; MGC104179; AA690181; I15RA; IL 15R alpha; Interleukin 15 receptor alpha; Interleukin 15 receptor subunit alpha; sIL-15 receptor subunit alpha; sIL-15RA; sIL-15R-alpha; Soluble interleukin 15 receptor subunit alpha; Soluble interleukin-15 receptor subunit alpha

UniProt

Q13261

Accession Number

Q13261-3

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ile31-Thr172

Applications

Cell culture

Field of Research

Signal Transduction; Cell biology; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.0 kDa

Observed Molecular Weight

60-75 kDa

Species

Human