Recombinant Human IL15RA&IL15 Fusion Protein (Fc Tag)

Specifications

Catalog number

PKSH032567-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.

Abbreviation

IL15RA&IL15 Fusion

Synonyms

MGC; IL15RA; CD215; alpha; CD215 antigen; IL-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; interleukin 15 receptor; interleukin-15 receptor subunit alpha; MGC104179; AA690181; I15RA; IL 15R alpha; Interleukin 15 receptor alpha; Interleukin 15 receptor subunit alpha; sIL-15 receptor subunit alpha; sIL-15RA; sIL-15R-alpha; Soluble interleukin 15 receptor subunit alpha; Soluble interleukin-15 receptor subunit alpha

UniProt

Q13261; P40933

Accession Number

Q13261&P40933

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ile31-Asp96&Asn49-Ser162 (Asn120Asp)

Applications

Cell culture

Field of Research

Signal Transduction; Cell biology; Cancer; immunology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

46.9 kDa

Observed Molecular Weight

50-60 kDa

Species

Human