Recombinant Human IL-2RB/CD122 Protein (Fc Tag)

Specifications

Catalog number

PKSH032572-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human IL-2RB; also known asinterleukin-2 receptor subunit beta; is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein; and has a 26 residue signal peptide; a 214 residue extracellular region; a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signaling via physically or functionally coupling to other signaling molecules; such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.

Abbreviation

IL-2RB; CD122

Synonyms

P70; IL2RB; CD122; IL15RB; P70-75; IL-2Rβ; p75; IL-2RB; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75 (p75) ; IL-2Rβ CD122 antigen; High affinity IL 2 receptor beta subunit; High affinity IL 2 receptor subunit beta; IL2 receptor; Interleukin 2 receptor beta; interleukin 2 receptor subunit beta; P70 75; P7075

UniProt

P14784

Accession Number

P14784

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ala27-Asp239

Applications

BLI

Field of Research

Signal Transduction; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Loaded Biotinylated Human IL-2-His-Avi on SA Biosensor, can bind Human IL-2RB-Fc with an affinity constant of 12.62nM as determined in BLI assay.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

51.7 kDa

Observed Molecular Weight

60-80 kDa

Species

Human