Recombinant Human IL-23 Recetor/IL-23R Protein (Fc Tag)

Specifications

Catalog number

PKSH032579-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits; the IL12Rβ1 subunit; which is shared with several cytokines; and a subunit that is unique to IL-23. IL23; after binding to IL23R; activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells; NK cells; dendritic cells; and macrophages. In fact; polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis; multiple sclerosis; Graves' s ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.

Abbreviation

IL-23 Recetor; IL-23R

Synonyms

IL23R; IL-23 receptor; IL-23R; Interleukin-23 receptor

UniProt

Q5VWK5

Accession Number

Q5VWK5

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gly24-Asp353

Applications

ELISA

Field of Research

Signal Transduction; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized Human IL-23R-Fc at 10μg/ml (100 μl/well) can bind Human IL-23-His.The ED50 of Human IL-23-His is 0.248 μg/ml.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

65.0 kDa

Observed Molecular Weight

90-120 kDa

Species

Human