Recombinant Human CD89/FCAR Protein (His Tag)

Specifications

Catalog number

PKSH032582-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Immunoglobulin α Fc Receptor (IgA Fc Receptor) is a member of the immunoglobulin gene superfamily. It is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens through the charged arginin residue within its transmembrane domain. IgA Fc Receptor binds both IgA1 and IgA2 with similar affinity. The site of interaction between FCAR and IgA was identified in the first extracellular domain of FCAR and the C2/C3 junction of IgA. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is also expressed on Kupffer cells in the liver, where it was suggested to provide a second line of defense.

Abbreviation

CD89; FCAR

Synonyms

CD89; CTB-61M7.2; FCAR; FcalphaRI; IgA Fc Receptor; Immunoglobulin Alpha Fc Receptor; XXbac-BPG230H20.5

UniProt

P24071

Accession Number

P24071

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln22-Asn227

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.5 kDa

Observed Molecular Weight

40 kDa

Species

Human