Recombinant Human IMP1/IMPA1 Protein (His Tag)

Specifications

Catalog number

PKSH032590-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Inositol Monophosphatase 1 (IMPA1) belongs to the inositol monophosphatase family. IMPA1 is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, IMPA1 can use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. IMPA1 has been implicated as the pharmacological target for lithium action in brain. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. In addition, IMPA1 plays a improtant role in intracellular signal transduction.

Abbreviation

IMP1; IMPA1

Synonyms

IMP 1; IMPA; IMPA1; IMPase 1; Inositol Monophosphatase 1; Inositol-1 (or 4) -Monophosphatase 1; Lithium-Sensitive Myo-Inositol Monophosphatase A1

UniProt

P29218

Accession Number

P29218

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Asp277

Field of Research

Signal Transduction; Neuroscience; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

32.3 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.25.

Species

Human