Recombinant Human IMPA2/IMPase 2 Protein (His Tag)

Specifications

Catalog number

PKSH032591-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Inositol monophosphatase 2, also known as Inositol-1 (or 4) -monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li (+) action in brain, it is considered to have a role in schizophrenia and bipolar disorder.

Abbreviation

IMPA2; IMPase 2

Synonyms

IMP 2; IMP.18P; IMPA2; IMPase 2; Inositol Monophosphatase 2; Inositol-1 (or 4) -Monophosphatase 2; Myo-Inositol Monophosphatase A2

UniProt

O14732

Accession Number

O14732

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Lys288

Field of Research

Signal Transduction; Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

33.5 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 2mM DTT, pH 8.0.

Species

Human