Recombinant Human ITM2B Protein (His Tag)

Specifications

Catalog number

PKSH032599-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) . CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.

Abbreviation

ITM2B

Synonyms

BRI; BRI2; Bri; ITM2B; Immature BRI2; Integral Membrane Protein 2B; Protein E25B; Transmembrane Protein BRI; imBRI2

UniProt

Q9Y287

Accession Number

Q9Y287

Expression System

HEK293 Cells

Tag

C-His

Sequence

Tyr76-Ser266

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

23.3 kDa

Observed Molecular Weight

29-33 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Acetate, 10% Trehalose, 25mM NaCl, 10% Glycerol, 0.05% Tween 80, pH 4.5.

Species

Human