Recombinant Human ICAM-1/CD54 Protein (Fc Tag)

Specifications

Catalog number

PKSH032601-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Inter-Cellular Adhesion Molecule 1 (ICAM1) is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. The presence of heavy glycosylation and other structural characteristics lend ICAM1 binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 (Mac-1; ITGB2 / ITGAM), leukocyte function associated antigen-1 (LFA-1/integrin), and fibrinogen.ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

Abbreviation

ICAM-1; CD54

Synonyms

CD54; ICAM-1; ICAM1; Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor

UniProt

P05362

Accession Number

P05362

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Asn26-Glu480

Field of Research

Cardiovascular; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

76.8 kDa

Observed Molecular Weight

90-125 kDa

Species

Human