Recombinant Human IFNAR1/IFNAR Protein (His Tag)

Specifications

Catalog number

PKSH032604-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-α and -β. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-α/β R1, in association with IFN-α/β R2, is required for propagating antiviral signal transduction triggered by IFN-α and IFN-β. IFN-α/β R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation. Human IFN-α/β R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.

Abbreviation

IFNAR1; IFNAR

Synonyms

AVP; CRF2-1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; IFN-Alpha/Beta Receptor 1; IFN-R-1; IFN-alpha-REC; IFNAR; IFNAR1; Interferon Alpha/Beta Receptor 1; Type I Interferon Receptor 1

UniProt

P17181

Accession Number

P17181

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys28-Lys436

Field of Research

Signal Transduction; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.2 kDa

Observed Molecular Weight

70-120 kDa

Species

Human