Recombinant Human IFNAR2 Protein (Fc Tag)

Specifications

Catalog number

PKSH032606-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interferon α/β Receptor 2 (IFN-α/β R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-α/β R1 to form the signaling receptor complex for the family of α and β IFN subtypes. By alternative splicing; IFN-α/β R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-α/β R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-α/β R1; resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes; monocytes; and granulocytes; although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets; IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase; JAK1. Isoform 1 also interacts with the transcriptional factors; STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.

Abbreviation

IFNAR2

Synonyms

IFN-Alpha Binding Protein; IFN-Alpha/Beta Receptor 2; IFN-R-2; IFNABR; IFNAR2; IFNARB; Interferon Alpha Binding Protein; Interferon Alpha/Beta Receptor 2; Type I Interferon Receptor 2

UniProt

P48551

Accession Number

P48551

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ile27-Lys243

Field of Research

Signal Transduction; Cancer; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

51.8 kDa

Observed Molecular Weight

67-75 kDa

Species

Human