Recombinant Human Interleukin-17A/IL-17A Protein

Specifications

Catalog number

PKSH032620-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha; it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis; and produced by rheumatoid arthritis synovium. It increases IL-6 production; induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Abbreviation

Interleukin-17A; IL-17A

Synonyms

Cytotoxic T-lymphocyte-associated antigen; IL17A; CTLA-8; CTLA8; IL-17; IL-17A; IL17; Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA 8; CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) ; Interleukin 17A; Interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003

UniProt

Q16552

Accession Number

Q16552

Expression System

E.coli

Tag

C-His

Sequence

Ile20-Ala155

Applications

Cell culture

Field of Research

Cancer; immunology

Endotoxin

< 0.01 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.5 kDa

Observed Molecular Weight

17 kDa

Species

Human