Recombinant Human Interleukin-17F/IL-17F Protein

Specifications

Catalog number

PKSH032623-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated; but not resting; CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines; including IL-6; IL-8; and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2; TGFB1/TGFB; and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6) .

Abbreviation

Interleukin-17F; IL-17F

Synonyms

Cytokine ML; Interleukin; CANDF; IL17F; CANDF6; IL-17F; ML-1; ML1; Cytokine ML-1; IL24; IL-24; Interleukin-17F; Interleukin-24

UniProt

Q96PD4

Accession Number

AAH70124.1

Expression System

HEK293 Cells

Tag

None

Sequence

Arg31-Gln163

Field of Research

Cardiovascular; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.9 kDa

Observed Molecular Weight

18 kDa

Species

Human