Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)

Specifications

Catalog number

PKSH032632-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-22 (IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

Abbreviation

IL-22

Synonyms

UNQ; IL-D; Interleukin; Cytokine Zcyto; TIFIL; zcyto; IL22; IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFIL-23; TIFa; zcyto18; UNQ3099/PRO10096; UNQ3099; Interleukin-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; PRO10096; IL-D110; ILTIF; IL-TIF; TIFa; TIFIL-23; zcyto18

UniProt

Q9GZX6

Accession Number

Q9GZX6

Expression System

HEK293 Cells

Tag

C-hIgG2 Fc

Sequence

Ala34-Ile179

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

43.4 kDa

Observed Molecular Weight

50-62 kDa

Species

Human