Recombinant Human Kallikrein 2/KLK2 Protein (His Tag)

Specifications

Catalog number

PKSH032666-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.

Abbreviation

Kallikrein 2; KLK2

Synonyms

Glandular Kallikrein-1; KLK2; Kallikrein-2; Tissue Kallikrein-2; hGK-1

UniProt

P20151

Accession Number

P20151

Expression System

HEK293 Cells

Tag

C-His

Sequence

Pro19-Pro261

Field of Research

Signal Transduction; Cell biology; Cancer

Endotoxin

< 0.01 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

27.9 kDa

Observed Molecular Weight

10-12&16-19&28-33 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Acetate, 250mM Trehalose, 0.02% Tween 80, pH5.0.

Species

Human