Recombinant Human KPNA2 Protein (His Tag)

Specifications

Catalog number

PKSH032670-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Karyopherin Subunit α-2 (KPNA2) belongs to the importin alpha family. KPNA2 is widely expressed in many tissues and contains an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. KPNA2 interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V (D) J recombination. KPNA2 functions in nuclear protein importantly as an adapter protein for nuclear receptor KPNB1.

Abbreviation

KPNA2

Synonyms

Importin Subunit Alpha-2; KPNA2; Karyopherin Subunit Alpha-2; RAG Cohort Protein 1; RCH1; SRP1; SRP1-Alpha

UniProt

P52292

Accession Number

P52292

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Phe529

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

60.0 kDa

Observed Molecular Weight

46-63 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 20% Glycerol, pH 8.0.

Species

Human