Recombinant Human KEL/CD238 Protein (His Tag)

Specifications

Catalog number

PKSH032671-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that carries the Kx antigen.

Abbreviation

KEL; CD238

Synonyms

CD238; KEL; Kell blood group glycoprotein

UniProt

P23276

Accession Number

P23276

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asn68-Trp732

Field of Research

Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

76.4 kDa

Observed Molecular Weight

85-120 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Species

Human