Recombinant Human KIR2DL3/NKAT2 Protein (Fc Tag)

Specifications

Catalog number

PKSH032674-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8) . KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

Abbreviation

KIR2DL3; NKAT2

Synonyms

CD158 antigen-like family member B2; CD158b2; KIR-023GB; KIR2DL3; Killer cell immunoglobulin-like receptor 2DL3; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT-2; NKAT2; p58 NK receptor CL-6

UniProt

P43628

Accession Number

P43628

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

His22-His245

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

51.7 kDa

Observed Molecular Weight

70-80 kDa

Species

Human