Recombinant Human LAMP1/CD107a Protein (Fc Tag)

Specifications

Catalog number

PKSH032683-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes; endosomes; and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers; as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium; therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

Abbreviation

LAMP1; CD107a

Synonyms

CD107 Antigen-Like Family Member A; CD107a; LAMP-1; LAMP1; LAMPA; LGP120; Lysosome-Associated Membrane Glycoprotein 1; Lysosome-Associated Membrane Protein 1

UniProt

P11279

Accession Number

P11279

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ala29-Met382

Field of Research

Signal Transduction; Tags & Cell Markers; Neuroscience; Cancer; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

65.5 kDa

Observed Molecular Weight

90-130 kDa

Species

Human