Recombinant Human LAMP2/CD107b Protein (His Tag)

Specifications

Catalog number

PKSH032684-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lysosomal Associated Membrane Protein 2 (LAMP2) is a major component of lysosomal membranes. LAMP2 is a transmembrane glycoprotein about 110kDa. Mature human LAMP2 consists of a 347 amino acid (aa) intralumenal domain, a 24 aa transmembrane segment, and a 35 aa cytoplasmic tail . The lumenal domain is organized into two heavily N-glycosylated regions. Alternate splicing generates a human LAMP2 isoform (LAMP2B) with a substituted juxtamembrane lumenal region, cytoplasmic tail and transmenmbrane segment.LAMP2 itself can cleavage lysosomal luminal domain and degradation lysosomal. In the help of chaperone HSC73, LAMP2 mediates the lysosomal uptake in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles.

Abbreviation

LAMP2; CD107b

Synonyms

CD107 Antigen-Like Family Member B; CD107b; LAMP-2; LAMP2; Lysosome-Associated Membrane Glycoprotein 2; Lysosome-Associated Membrane Protein 2

UniProt

P13473

Accession Number

P13473

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu29-Ile375

Field of Research

Signal Transduction; Tags & Cell Markers; Cardiovascular; Cancer; immunology; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

39.4 kDa

Observed Molecular Weight

60-120 kDa

Species

Human