Recombinant Human CD300a/LMIR1 Protein (Fc & His Tag)

Specifications

Catalog number

PKSH032700-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b; CD300e) and inhibitory members (CD300a; CD300f) ; as well as molecules presenting a negative charge within their transmembrane domain (CD300c; CD300d) . It is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells.

Abbreviation

CD300a; LMIR1

Synonyms

CD300 Antigen-Like Family Member A; CD300A; CD300a; CLM-8; CMRF-35-H9; CMRF35-H; CMRF35-H9; CMRF35-Like Molecule 8; CMRF35H; IGSF12; IRC1/IRC2; IRp60; IgSF12; Immunoglobulin Superfamily Member 12; Inhibitory Receptor Protein 60; NK Inhibitory Receptor

UniProt

Q9UGN4

Accession Number

Q9UGN4

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Leu18-Gln178

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

45.4 kDa

Observed Molecular Weight

60-75 kDa

Species

Human