Recombinant Human LMCD1/Dyxin Protein (His Tag)

Specifications

Catalog number

PKSH032706-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Abbreviation

LMCD1; Dyxin

Synonyms

Dyxin; LIM and cysteine-rich domains protein 1; LMCD1

UniProt

Q9NZU5

Accession Number

Q9NZU5

Expression System

E.coli

Tag

N-His & C-His

Sequence

Met 1-Ser365

Field of Research

Signal Transduction; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

44.0 kDa

Observed Molecular Weight

45 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0.

Species

Human