Recombinant Human LDLR Protein (His Tag/AVI)

Specifications

Catalog number

PKSH032711-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.

Abbreviation

LDLR

Synonyms

FH; FHC; LDL R; LDL Receptor; LDLCQ2; LDLR; Low-Density Lipoprotein Receptor

UniProt

P01130

Accession Number

P01130

Expression System

HEK293 Cells

Conjugation

Biotinylated

Tag

C-Avi-His

Sequence

Ala22-Arg788

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

88.4 kDa

Observed Molecular Weight

95-140 kDa

Species

Human