Recombinant Human LYVE1/HAR Protein (His Tag)

Specifications

Catalog number

PKSH032725-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS) . It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Abbreviation

LYVE1; HAR

Synonyms

CRSBP-1; CRSBP1; Cell Surface Retention Sequence-Binding Protein 1; Extracellular Link Domain-Containing Protein 1; HAR; Hyaluronic Acid Receptor; LYVE-1; LYVE1; Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1; XLKD1

UniProt

Q9Y5Y7

Accession Number

AAH26231.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu20-Thr 238

Field of Research

Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.6 kDa

Observed Molecular Weight

46 kDa

Species

Human