Recombinant Human Tau-F Protein

Specifications

Catalog number

PKSH032756-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Abbreviation

Tau-F

Synonyms

MAPTL; MTBT1; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; TAU and MAPT

UniProt

P10636

Accession Number

P10636-8

Expression System

E.coli

Tag

None

Sequence

Met 1-Leu441

Field of Research

Neuroscience, Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

45.9 kDa

Observed Molecular Weight

60 kDa

Species

Human