Recombinant Human MINPP1 Protein (His Tag)

Specifications

Catalog number

PKSH032767-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) . MINPP1 may play a role in bone development (endochondral ossification) .

Abbreviation

MINPP1

Synonyms

2,3-BPG Phosphatase;2,3-Bisphosphoglycerate 3-Phosphatase; Inositol (1,3,4,5) -Tetrakisphosphate 3-Phosphatase; Ins (1,3,4,5) P (4) 3-Phosphatase; MINPP1; MIPP; Multiple Inositol Polyphosphate Phosphatase 1

UniProt

Q9UNW1

Accession Number

Q9UNW1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser31-Leu487

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

53.1 kDa

Observed Molecular Weight

56 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.

Species

Human