Recombinant Human Myelin Protein P0/MPZ Protein (His Tag)

Specifications

Catalog number

PKSH032770-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ is a major component of the myelin sheath in peripheral nerves. It is postulated that MPZ is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively-charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer, and by interaction between hydrophobic globular of adjacent extracellular domains. Defects in MPZ associated with Charcot-Marie-Tooth disease and Dejerine-Sottas disease.

Abbreviation

MyelinP0; MPZ

Synonyms

MPP; MPZ; Myelin Peripheral Protein; Myelin Protein P0; Myelin Protein Zero

UniProt

P25189

Accession Number

P25189

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ile30-Arg153

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

15.2 kDa

Observed Molecular Weight

14-17 kDa

Species

Human