Recombinant Human NCR3/NKp30 Protein (Fc Tag)

Specifications

Catalog number

PKSH032787-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition; NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.

Abbreviation

NCR3; NKp30

Synonyms

1C7; Activating Natural Killer Receptor p30; CD337; DAAP-90L16.3; LY117; MALS; NCR3; NK-p30; NKp30; Natural Cytotoxicity Triggering Receptor 3; Natural Killer Cell p30-Related Protein

UniProt

O14931

Accession Number

O14931

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Leu19-Thr138

Field of Research

Immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

40.2 kDa

Observed Molecular Weight

50-60 kDa

Species

Human