Recombinant Human Nectin-3/PVRL3 Protein (His Tag)

Specifications

Catalog number

PKSH032789-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Nectin-3 is a type I transmembrane glycoprotein that belongs to the nectin family. Its precursor is 549 amino acids in length and contains an extended signal sequence of 57 amino acids, an extracellular domain (ECD) of 347 amino acids, a transmembrane segment of 21 amino acids, and a cytoplasmic region of 124 amino acids. It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. Nectin-3 is also involved in the formation of cell-cell junctions, including adherens junctions and synapses.

Abbreviation

Nectin-3; PVRL3

Synonyms

CD113; CDw113; Nectin-3; PRR3; PVRL3; PVRR3; Poliovirus Receptor-Related Protein 3

UniProt

Q9NQS3

Accession Number

Q9NQS3

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gly58-Cys366

Field of Research

Microbiology; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

35.0 kDa

Observed Molecular Weight

54 kDa

Species

Human