Recombinant Human NCAM1 Protein (His Tag)

Specifications

Catalog number

PKSH032793-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neural cell adhesion molecule 1 (NCAM-1) is a single-pass type I membrane protein, it belongs to a family of membrane-bound glycoproteins that are involved in Ca2+ independent cell matrix and homophilic or heterophilic cell-cell interactions. NCAM-1 is synthesized as a 761 aa preproprecursor that contains a 19 aa signal sequence, a 722 aa GPI-linked mature region, and a 20 aa C-terminal prosegment. The molecule contains five C-2 type Ig-like domains and two fibronectin type-III domains. NCAM-1 is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Acting as a receptor for rabies virus, NCAM-1 in the adult brain shows a decline of sialylation relative to earlier developmental periods.

Abbreviation

NCAM1

Synonyms

CD56; CD56 antigen; MSK39; N-CAM-1; NCAM; NCAM-1; neural cell adhesion molecule; neural cell adhesion molecule 1

UniProt

P13591

Accession Number

P13591-3

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu20-Pro603

Field of Research

Neuroscience, Stem Cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

65.5 kDa

Observed Molecular Weight

90-120 kDa

Species

Human