Recombinant Human NKG2A & CD94 Heterodimer Protein (His & Flag Tag)

Specifications

Catalog number

PKSH032812-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

NKG2-A/NKG2-B Type II Integral Membrane Protein contains 1 C-type lectin domain and belongs to the killer cell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of natural killer cells in the innate immune system. CD94 Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. CD94 Can form disulfide-bonded heterodimer with NKG2 family members. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA) -E on target cells.

Abbreviation

NKG2A & CD94 Heterodimer

Synonyms

CD159A&KLRD1 Heterodimer ; KLRC1&CD94 Heterodimer; NKG2A&CD94 Heterodimer

UniProt

P26715; Q13241

Accession Number

P26715&Q13241

Expression System

HEK293 Cells

Tag

N-His & N-Flag

Sequence

Arg100-Leu233 & Ser34-Ile179

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

34.4 kDa

Observed Molecular Weight

25-40 kDa

Species

Human