Recombinant Human NME1/NDKA Protein (His Tag)

Specifications

Catalog number

PKSH032830-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Nucleoside-Diphosphate Kinases (NDKs) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDKs Possesse nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. NDKs involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression and required for neural development including neural patterning and cell fate determination. Prokaryotic NDK forms a functional homotetramer.There are two isoforms of NDK in humans: NDK-A and NDK-B. Both have very similar structure, and can combine in any proportion to form functional NDK hexamers.

Abbreviation

NME1; NDKA

Synonyms

AWD; GAAD; Granzyme A-Activated DNase; Metastasis Inhibition Factor nm23; NB; NBS; NDK A; NDKA; NDP Kinase A; NDPK-A; NDPKA; NM23; NM23-H1; NME1; Nucleoside Diphosphate Kinase A; Tumor Metastatic Process-Associated Protein; nm23-H1

UniProt

P15531

Accession Number

P15531

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Glu152

Field of Research

Cancer; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

19.3 kDa

Observed Molecular Weight

21 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 7.5.

Species

Human