Recombinant Human OX-2/MOX1/CD200 Protein (Fc Tag)

Specifications

Catalog number

PKSH032841-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD200 is a transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. It contains one Ig like V type domain and one Ig like C2 type domain in its extracelluar domain. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells; basophils; macrophages; and dendritic cells; which suggests myeloid cell regulation as the major function of CD200. CD200 and CD200R associate via their respective N-terminal Ig-like domains. In myeloid cells; CD200R initiates inhibitory signals following receptor-ligand contact. In T cells; CD200 functions as a co-stimulatory molecule independent of the CD28 pathway. In addition; CD200 also plays an important role in prevention of graft rejection; autoimmune diseases and spontaneous abortion.

Abbreviation

OX-2; MOX1; CD200

Synonyms

CD200; MOX1; MOX2; OX-2 Membrane Glycoprotein

UniProt

P41217

Accession Number

P41217

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln31-Gly232

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

49.5 kDa

Observed Molecular Weight

65-90 kDa

Species

Human