Recombinant Human FKBP3/FKBP25 Protein (His Tag)

Specifications

Catalog number

PKSH032876-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FKBP25 contains 1 PPIase FKBP-type domain; belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin; as well as histone deacetylases; the transcription factor YY1; casein kinase II; and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Abbreviation

FKBP3; FKBP25

Synonyms

25 kDa FK506-binding protein;25 kDa FKBP; FK506-binding protein 3; FKBP-25; FKBP-3; FKBP25; Immunophilin FKBP25; PPIase FKBP3; Peptidyl-prolyl cis-trans isomerase FKBP3; Rapamycin-selective 25 kDa immunophilin; Rotamase

UniProt

Q00688

Accession Number

Q00688

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Asp224

Field of Research

Epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

27.3 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 8.0.

Species

Human