Recombinant Human FKBP4 Protein (His Tag)

Specifications

Catalog number

PKSH032877-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.

Abbreviation

FKBP4

Synonyms

51kDa FK506-binding protein;59kDa immunophilin; FK506-binding protein 4; FKBP4; FKBP59; HSP-binding immunophilin; Peptidyl-prolyl cis-trans isomerase FKBP4; Rotamase; immunophilin FKBP52

UniProt

Q02790

Accession Number

Q02790

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Ala459

Field of Research

Signal Transduction; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

52.8 kDa

Observed Molecular Weight

50-60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0.

Species

Human