Recombinant Human Peroxiredoxin 1/PRDX1 Protein (His Tag)

Specifications

Catalog number

PKSH032881-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Peroxiredoxin-1 (PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8 (+) T-cells and have a proliferative effect in cancer development or progression.

Abbreviation

Peroxiredoxin 1; PRDX1

Synonyms

MSP23; NKEF-A; NKEFA; Natural killer cell-enhancing factor A; PAG; PAGA; PAGB; PRX1; PRXI; Peroxiredoxin-1; Proliferation-associated gene protein; TDPX2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2

UniProt

Q06830

Accession Number

Q06830

Expression System

E.coli

Tag

N-His & C-His

Sequence

Met 1-Lys199

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

25.3 kDa

Observed Molecular Weight

26 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 10% glycerol, 0.1mM DTT, pH 6.0.

Species

Human