Recombinant Human Peroxiredoxin-3/PRDX3 Protein

Specifications

Catalog number

PKSH032882-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Human PRDX3 protein has an antioxidant function and is localized in the mitochondrion. PRDX3 is involved in redox regulation of the cell. PRDX3 protects radical-sensitive enzymes from oxidative damage by a radical-generating system. It acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.

Abbreviation

Peroxiredoxin-3; PRDX3

Synonyms

AOP-1; AOP1; Antioxidant Protein 1; HBC189; PRDX3; Peroxiredoxin III; Peroxiredoxin-3; Protein MER5 homolog; Prx-III; Thioredoxin-Dependent Peroxide Reductase Mitochondrial

UniProt

P30048

Accession Number

P30048

Expression System

E.coli

Tag

None

Sequence

Pro63-Gln256

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

21.6 kDa

Observed Molecular Weight

25 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0.

Species

Human