Recombinant Human PSPH Protein (His Tag)

Specifications

Catalog number

PKSH032897-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation; moderate psychomotor retardation and facial features suggestive of Williams syndrome.

Abbreviation

PSPH

Synonyms

L-3-Phosphoserine Phosphatase; O-Phosphoserine Phosphohydrolase; PSP; PSPH; PSPase; Phosphoserine Phosphatase

UniProt

P78330

Accession Number

P78330

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Glu225

Field of Research

Signal Transduction; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

26.1 kDa

Observed Molecular Weight

25-30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 4M Urea, 5mM EDTA, pH 8.0.

Species

Human