Recombinant Human PDGF-AA Protein

Specifications

Catalog number

PKSH032904-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Platelet-derived growth factor subunit A (PDGFA) ; belongs to the PDGF/VEGF growth factor family. PDGFA is a secreted protein; stored in platelet alpha-granules and released by platelets upon wounding. PDGFA is potent mitogens for a variety of cell types including smooth muscle cells; connective tissue cells; bone and cartilage cells; and some blood cells. It plays an essential role in the regulation of embryonic development; cell proliferation; cell migration; survival and chemotaxis. PDGFA is required for normal lung alveolar septum formation during embryogenesis; normal development of the gastrointestinal tract; normal development of Leydig cells and spermatogenesis; normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. It plays an important role in wound healing; Signaling is modulated by the formation of heterodimers with PDGFB.

Abbreviation

PDGF-AA

Synonyms

PDGF subunit A; PDGF-1; PDGF1; PDGFA; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A

UniProt

P04085

Accession Number

P04085

Expression System

E.coli

Tag

None

Sequence

Ser87-Thr 211

Field of Research

Signal Transduction; Cardiovascular; Cancer; Developmental Biology; immunology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.4 kDa

Observed Molecular Weight

16 kDa

Species

Human