Recombinant Human TEM7/PLXDC1 Protein (His Tag)

Specifications

Catalog number

PKSH032908-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Plexin Domain-Containing Protein 1 (PLXDC1) is a single-pass type I membrane protein that belongs to the plexin family. Secreted PLXDC1 is localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. PLXDC1 is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. It can detect in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. PLXDC1 interacts with NID1 and may also interact with CTTN. It plays a important role in endothelial cell capillary morphogenesis, the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs) .

Abbreviation

TEM7; PLXDC1

Synonyms

PLXDC1; Plexin Domain-Containing Protein 1; TEM3; TEM7; Tumor Endothelial Marker 3; Tumor Endothelial Marker 7

UniProt

Q8IUK5

Accession Number

AAH36059.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu19-Thr426

Field of Research

Tags & Cell Markers; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

46.5 kDa

Observed Molecular Weight

60-90 kDa

Species

Human