Recombinant Human Podoplanin/PDPN Protein (Fc Tag)

Specifications

Catalog number

PKSH032910-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta; lung; skeletal muscle and brain; weakly expressed in brain; kidney and liver. In placenta; PDPN expressed on the apical plasma membrane of endothelium; in lung; expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes; induces changes in cell morphology with transfected cells showing an elongated shape; numerous membrane protrusions; and major reorganization of the actin cytoskeleton; increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless; it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

Abbreviation

Podoplanin; PDPN

Synonyms

Aggrus; GP36; Glycoprotein 36; Gp36; PA2.26 Antigen; PDPN; Podoplanin; T1-Alpha; T1A

UniProt

Q86YL7

Accession Number

Q86YL7

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ala23-Leu131

Field of Research

Tags & Cell Markers; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.3 kDa

Observed Molecular Weight

60-70 kDa

Species

Human