Recombinant Human PSG9/PSBG9 Protein (His Tag)

Specifications

Catalog number

PKSH032927-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pregnancy-specific beta-1-glycoprotein 9 (PSG9) is a secreted protein and contains 3 Ig-like C2-type (immunoglobulin-like) domains, 1 Ig-like V-type (immunoglobulin-like) domain. It is a member of the PSG family, a group of closely related secreted glycoproteins that are highly expressed in fetal placental syncytiotrophoblast cells. The members of the PSG protein family all have a characteristic N-terminal domain that is homologous to the immunoglobulin variable region. PSGs become detectable in serum during the first two to three weeks of pregnancy and increase as the pregnancy progresses, eventually representing the most abundant fetal protein in the maternal blood at term. PSGs function to stimulate secretion of TH2-type cytokines from monocytes, and they may also modulate the maternal immune system during pregnancy, thereby protecting the semi-allotypic fetus from rejection. PSGs are commonly expressed in trophoblast tumors. Eleven human PSG proteins (PSG1-PSG11) have been described.

Abbreviation

PSG9; PSBG9

Synonyms

PS-beta-B; PS-beta-G-11; PS-beta-G-9; PS34; PSBG-11; PSBG-9; Pregnan; Pregnancy-specific beta-1 glycoprotein B; Pregnancy-specific beta-1-glycoprotein 11; Pregnancy-specific beta-1-glycoprotein 9; Pregnancy-specific glycoprotein 11; Pregnancy-specific glycoprotein 9

UniProt

Q00887

Accession Number

AAH20759.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu35-Ser426

Field of Research

Tags & Cell Markers

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

45.6 kDa

Observed Molecular Weight

65 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Species

Human