Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 2-246)

Specifications

Catalog number

PKSH032939-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pro-neuregulin-1; Neuregulin-1 beta 1 (NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial; glial; neuronal; and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Abbreviation

Pro-Neuregulin-1; NRG1-β1

Synonyms

EGF; GGF; HGL; HRG1-beta 1; HRGA; NDF; NRG1; NRG1-beta 1; Neuregulin-1 beta 1; Pro-neuregulin-1; SMDF

UniProt

Q02297

Accession Number

AAA58639.1

Expression System

E.coli

Tag

None

Sequence

Ser2-Lys246

Field of Research

Neuroscience

Endotoxin

< 0.01 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

26.9 kDa

Observed Molecular Weight

34 kDa

Species

Human